Yoshiharu Karube Selected Research

gamma-tocopherol-N,N-dimethylglycinate hydrochloride

7/2006	Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin.
6/2006	Topical application of gamma-tocopherol derivative prevents UV-induced skin pigmentation.
7/2005	Topical application of a novel, water-soluble gamma-tocopherol derivative prevents UV-induced skin damage in mice.

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Yoshiharu Karube Research Topics

Disease

5	Infections 04/2017 - 12/2011
4	Thrombocytopenia (Thrombopenia) 01/2017 - 02/2011
3	Phototoxic Dermatitis (Phototoxicity) 12/2020 - 05/2019
3	Hepatocellular Carcinoma (Hepatoma) 07/2018 - 02/2015
3	Neoplasms (Cancer) 01/2017 - 03/2012
3	Inflammation (Inflammations) 08/2012 - 07/2005
2	Alzheimer Disease (Alzheimer's Disease) 08/2018 - 01/2018
2	Pheochromocytoma 08/2018 - 01/2014
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2017 - 04/2008
2	Wounds and Injuries (Trauma) 12/2013 - 11/2003
2	Body Weight (Weight, Body) 09/2013 - 08/2012
2	Anemia 12/2011 - 02/2011
2	Edema (Dropsy) 07/2006 - 07/2005
1	Osteoporosis 05/2021
1	Acute Promyelocytic Leukemia 05/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 09/2020
1	Schizophrenia (Dementia Praecox) 09/2020
1	Nervous System Diseases (Neurological Disorders) 08/2018
1	Mood Disorders (Mood Disorder) 08/2018
1	Chronic Renal Insufficiency 01/2017
1	Communicable Diseases (Infectious Diseases) 12/2015
1	Pneumonia (Pneumonitis) 12/2015
1	Soft Tissue Infections 12/2013
1	Sepsis (Septicemia) 01/2013
1	Endocarditis 08/2012
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 03/2012
1	Bacterial Meningitis 12/2011
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 05/2007
1	Neuroblastoma 05/2007
1	Experimental Melanoma 06/2006
1	Sunburn 07/2005

Drug/Important Bio-Agent (IBA)

9	Linezolid (Zyvox)FDA Link 01/2017 - 04/2008
4	ProdrugsIBA 11/2020 - 07/2015
4	menahydroquinone-4IBA 05/2019 - 02/2015
3	Pharmaceutical PreparationsIBA 05/2021 - 08/2012
3	menatetrenoneIBA 05/2021 - 02/2015
3	gamma-tocopherol-N,N-dimethylglycinate hydrochlorideIBA 07/2006 - 07/2005
2	Singlet OxygenIBA 12/2020 - 11/2020
2	Nerve Growth Factor (NGF)IBA 08/2018 - 01/2014
2	Prothrombin (Factor II)IBA 07/2015 - 02/2015
2	Hemoglobins (Hemoglobin)IBA 09/2013 - 12/2011
2	gamma-TocopherolIBA 07/2006 - 01/2003
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 05/2021
1	Vitamin K 1 (Phylloquinone)FDA LinkGeneric 12/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2020
1	coenzyme Q10 (CoQ10)IBA 11/2020
1	ubiquinol-10IBA 11/2020
1	Superoxides (Superoxide)IBA 11/2020
1	EstersIBA 11/2020
1	Neuroprotective AgentsIBA 09/2020
1	menatetrenone epoxideIBA 05/2019
1	Yi-Gan SanIBA 08/2018
1	Nerve Growth Factors (Neurotrophins)IBA 08/2018
1	Cholinesterases (Cholinesterase)IBA 01/2018
1	Rivastigmine (Exelon)FDA LinkGeneric 01/2018
1	ButyrylcholinesteraseIBA 01/2018
1	AcetylcholinesteraseIBA 01/2018
1	Daptomycin FDA Link 04/2017
1	CreatinineIBA 12/2015
1	Vancomycin FDA LinkGeneric 12/2015
1	Vitamin K 2 (Vitamin K2)IBA 02/2015
1	Antineoplastic Agents (Antineoplastics)IBA 02/2015
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2014
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	sultamicillin (ampicillin-sulbactam)FDA LinkGeneric 12/2013
1	Carbapenems (Carbapenem Antibiotics)IBA 12/2013
1	Meropenem (Merrem)FDA LinkGeneric 12/2013
1	TransferasesIBA 09/2013
1	Alanine (L-Alanine)FDA Link 09/2013
1	Gentamicins (Gentamicin)FDA LinkGeneric 08/2012
1	Carboplatin (JM8)FDA LinkGeneric 03/2012
1	chrysoidineIBA 05/2007
1	Quinacrine (Mepacrine)IBA 05/2007
1	PrionsIBA 05/2007
1	Messenger RNA (mRNA)IBA 07/2006
1	Acetates (Acetic Acid Esters)FDA Link 07/2006
1	Dinoprostone (PGE2)FDA Link 07/2006
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2006
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2006
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 07/2006
1	AntioxidantsIBA 07/2006
1	kojic acidIBA 06/2006
1	Melanins (Melanin)IBA 06/2006
1	Monophenol Monooxygenase (Tyrosinase)IBA 06/2006
1	SolutionsIBA 07/2005
1	Propylene Glycol (1,2 Propanediol)FDA LinkGeneric 07/2005
1	Ethanol (Ethyl Alcohol)IBA 07/2005
1	SugarsIBA 11/2003
1	delta-tocopherolIBA 01/2003
1	alpha-Tocopherol FDA Link 01/2003
1	delta tocotrienolIBA 01/2003
1	alpha tocotrienolIBA 01/2003
1	plastochromanol 8IBA 01/2003
1	Protein Isoforms (Isoforms)IBA 01/2003

Therapy/Procedure

3	Therapeutics 07/2015 - 05/2007
3	Renal Dialysis (Hemodialysis) 01/2013 - 04/2008
1	Topical Administration 11/2020
1	Kampo Medicine (Kampo) 08/2018
1	Nephrectomy 01/2017
1	Drug Therapy (Chemotherapy) 03/2012